Philip J Rosenthal Selected Research

Antimalarials (Antimalarial Agents)

10/2022	Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
1/2022	Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
11/2021	Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study.
11/2020	Associations between Malaria-Preventive Regimens and Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Ugandan Pregnant Women.
11/2020	Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
1/2020	Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria.
1/2020	Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity.
1/2020	Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.
12/2019	Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates.
10/2019	Antimalarial drug resistance in Africa: the calm before the storm?

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Philip J Rosenthal Research Topics

Disease

216	Malaria 10/2022 - 01/2002
40	Infections 01/2022 - 12/2002
35	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2021 - 02/2003
25	Parasitemia 01/2021 - 05/2006
7	Fever (Fevers) 11/2021 - 06/2007
7	Rupture 01/2011 - 01/2002
6	HIV Infections (HIV Infection) 11/2014 - 01/2006
5	Parasitic Diseases (Parasitic Disease) 01/2022 - 01/2005
5	Reinfection 03/2015 - 02/2003
4	Glucosephosphate Dehydrogenase Deficiency 01/2018 - 08/2008
3	Trachoma 12/2019 - 05/2014
3	Cryptosporidiosis 01/2019 - 12/2008
2	African Trypanosomiasis (Nagana) 01/2022 - 09/2009
2	Communicable Diseases (Infectious Diseases) 02/2021 - 12/2008
2	Hemolysis 12/2019 - 09/2004
2	Neglected Diseases 01/2019 - 01/2017
2	Body Weight (Weight, Body) 01/2019 - 11/2012
2	Thalassemia 01/2018 - 11/2017
2	Toxoplasmosis 10/2016 - 12/2008
2	Acute malaria 09/2013 - 05/2012
2	Pruritus (Itching) 11/2012 - 02/2007
2	Seizures (Absence Seizure) 06/2009 - 01/2008

Drug/Important Bio-Agent (IBA)

69	Antimalarials (Antimalarial Agents)IBA 10/2022 - 05/2002
36	Pharmaceutical PreparationsIBA 01/2022 - 04/2002
33	artemisinin (artemisinine)IBA 04/2022 - 07/2005
32	pyrimethamine drug combination fanasil (Fansidar)FDA Link 01/2022 - 12/2002
30	Cysteine Proteases (Cysteine Protease)IBA 01/2022 - 01/2002
28	artenimol (dihydroartemisinin)IBA 01/2022 - 05/2007
28	piperaquineIBA 01/2022 - 05/2007
28	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2021 - 05/2006
25	Amodiaquine (Camoquin)FDA Link 01/2019 - 12/2002
20	falcipain 2IBA 01/2022 - 04/2002
19	Hemoglobins (Hemoglobin)IBA 01/2018 - 03/2002
17	ArtesunateIBA 01/2019 - 12/2002
16	Chloroquine (Aralen)FDA LinkGeneric 10/2019 - 02/2003
13	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 03/2002
8	falcipain 3IBA 01/2020 - 01/2003
8	PapainIBA 01/2020 - 01/2002
8	Proteins (Proteins, Gene)FDA Link 08/2015 - 03/2002
7	InsecticidesIBA 10/2020 - 01/2012
7	EnzymesIBA 09/2013 - 08/2006
6	AntigensIBA 01/2020 - 12/2004
6	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 11/2014 - 09/2006
5	Protease Inhibitors (Protease Inhibitor)IBA 01/2022 - 12/2004
5	falcipainIBA 01/2020 - 08/2004
5	Azithromycin (Zithromax)FDA LinkGeneric 12/2019 - 05/2014
5	Folic Acid AntagonistsIBA 10/2019 - 02/2003
5	Lopinavir FDA Link 01/2017 - 11/2011
5	Ritonavir (Norvir)FDA Link 01/2017 - 11/2011
5	insulin receptor-related receptor (IRR)IBA 08/2014 - 12/2004
5	Amino Acids FDA Link 07/2013 - 11/2002
4	VaccinesIBA 11/2020 - 05/2008
4	Merozoite Surface Protein 1 (MSA1)IBA 12/2019 - 02/2003
4	Biological ProductsIBA 12/2019 - 05/2005
4	Lumefantrine FDA Link 12/2017 - 08/2009
4	Histidine (L-Histidine)FDA Link 09/2017 - 06/2007
4	Peptides (Polypeptides)IBA 01/2017 - 03/2006
4	Reverse Transcriptase InhibitorsIBA 08/2014 - 11/2012
4	Cysteine Proteinase InhibitorsIBA 01/2010 - 12/2003
3	Pyrimethamine (Daraprim)FDA Link 01/2022 - 11/2004
3	Biomarkers (Surrogate Marker)IBA 12/2019 - 01/2012
3	Heme (Haem)IBA 05/2015 - 10/2010
3	Membrane Proteins (Integral Membrane Proteins)IBA 07/2011 - 12/2002
3	Quinine (Quinson)FDA Link 05/2011 - 07/2009
3	hemozoinIBA 04/2009 - 05/2005
2	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 01/2022 - 09/2006
2	Proguanil (Paludrine)FDA Link 01/2022 - 07/2013
2	Immunoglobulin G (IgG)IBA 01/2020 - 01/2012
2	AminoquinolinesIBA 12/2019 - 10/2019
2	2- methyl- 3- (4- phenylpiperidino)propionohydroxamic acid hydrochloride (K 76)IBA 01/2019 - 01/2015
2	Indicators and Reagents (Reagents)IBA 01/2019 - 09/2009
2	efavirenz (Sustiva)FDA Link 01/2018 - 11/2012
2	glucose-6-phosphate dehydrogenase A-IBA 11/2017 - 12/2004
2	Sickle HemoglobinIBA 11/2017 - 12/2004
2	GlobinsIBA 11/2017 - 05/2005
2	rhodesainIBA 01/2017 - 09/2009
2	Ligases (Synthetase)IBA 10/2016 - 08/2013
2	8-aminoquinolineIBA 05/2015 - 02/2014
2	Hemin (Panhematin)FDA Link 05/2015 - 04/2015
2	DNA (Deoxyribonucleic Acid)IBA 09/2013 - 08/2013
2	TetracyclinesIBA 07/2013 - 09/2006
2	KininsIBA 02/2013 - 05/2012
2	IronIBA 12/2012 - 11/2010
2	Primaquine FDA Link 03/2012 - 10/2011
2	AntibodiesIBA 01/2012 - 07/2011
2	RNA (Ribonucleic Acid)IBA 07/2010 - 06/2008
2	Folic Acid (Vitamin M)FDA LinkGeneric 06/2010 - 11/2006
2	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 09/2009 - 12/2004
2	Midazolam (Versed)FDA LinkGeneric 06/2009 - 01/2008
2	Diazepam (Valium)FDA LinkGeneric 06/2009 - 01/2008
2	Chalcone (Benzalacetophenone)IBA 04/2009 - 05/2005

Therapy/Procedure

66	Therapeutics 10/2022 - 12/2002
15	Chemoprevention 01/2022 - 07/2014
8	Aftercare (After-Treatment) 03/2015 - 05/2006
4	Drug Therapy (Chemotherapy) 06/2021 - 01/2002
4	Insecticide-Treated Bednets 01/2020 - 10/2007
4	Art Therapy 04/2014 - 04/2012
2	Mass Drug Administration 01/2019 - 09/2017
2	Microspheres (Microsphere) 10/2016 - 08/2014
2	Oral Administration 12/2013 - 11/2012